Table 3: Correlation coefficients of the physical domain scores of WHOQOL-BREF with the severity of clinical symptoms and level of functioning in bipolar disorder group at baseline, 4-, 8-, 12-month assessments.

AssessmentModelUnstandardized coefficientsStandardized coefficients value R squareAdjusted R squareCollinearity statistics (VIF)
St. ErBeta

Baseline ( )1HDRS−1.870.35−0.59−5.42<0.0010.590.350.341.00
2HDRS−2.110.33−0.67−6.41<0.0010.67
0.45
0.43
1.06
CGI5.301.700.333.12<0.011.06

4-month ( )1HDRS−0.160.07−0.33−2.36<0.050.330.110.091.00

8-month ( )1HDRS−1.720.35−0.61−4.97<0.0010.610.370.361.00
2HDRS−2.190.33−0.77−6.61<0.0010.72
0.52
0.50
1.18
YMRS0.990.270.433.63<0.0011.18

12-month ( )1HDRS−0.970.27−0.48−3.60<0.0010.480.230.211.00
2HDRS−1.170.25−0.58−4.67<0.0010.62
0.39
0.37
1.07
Sex−13.934.29−0.41−3.25<0.011.07

HDRS: Hamilton-Depression Rating Scale.
CGI: Clinical Global Impression.
YMRS: Young Mania Rating Scale.