No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects

Table 1

Associations between depressive symptoms and BDNF, COMT, SLC6A3, MAOA, and SLC6A4 genes in a Colombian sample.

Gene/SNP	Genotypes	Frequencies (%)	HADS-D mean (SD)	HWE	value	value
BDNF-rs6265	G/G	145 (0.77)	3.46 (0.23)	0.094	0.98	0.88
	G/A	37 (0.19)	3.35 (0.44)
	A/A	6 (0.03)	3.5 (1.12)
COMT-rs4680	G/G	75 (0.40)	3.55 (0.32)	0.35	0.83	0.96
	G/A	92 (0.49)	3.40 (0.27)
	A/A	21 (0.11)	3.19 (0.62)
SLC6A3-rs28363170	10/10	117 (0.66)	3.6 (0.26)			0.34
	10/9	53 (0.30)	3.06 (0.34)	0.25	0.43
	9/9	10 (0.06)	3 (0.68)
MAOA-VNTR	4/4	77 (0.43)	3.42 (0.32)			0.11
	4/3	65 (0.36)	3.09 (0.28)	0.58	0.47
	3/3	38 (0.21)	3.63 (0.49)
SLC6A4-rs4795541	S/S	49 (0.26)	3.12 (0.4)			0.85
	S/L	92 (0.49)	3.68 (0.28)	0.88	0.47
	L/L	45 (0.24)	3.43 (0.42)

HWE calculated in females. Quantitative association with total scores for HADS-D. Categorical association with a cutoff point of 8 (normal and high HADS-D scores).
HWE: Hardy-Weinberg equilibrium ( value); BDNF: brain-derived neurotrophic factor; COMT: catechol-O-methyltransferase; SLC6A3: dopamine transporter; MAOA: monoamine oxidase A; SLC6A4: serotonin transporter.