Proton Pump Inhibitor Therapy before and after Endoscopic Submucosal Dissection: A Review

Table 2

Median intragastric pH during the first 24 and 48 h with different intravenous infusion regimens as a function of CYP2C19 genotype status.

Regimen	Periods	RM	IM	PM
Placebo	First 24 h	2.2 (1.3–3.6)	2.8 (1.8–3.5)	2.4 (1.5–2.9)
	First 48 h	2.1 (1.5–3.4)	2.8 (1.5–3.9)	2.4 (1.9–3.3)
Famotidine	First 24 h	4.4 (3.8–4.9)	4.1 (3.9–6.5)	4.7 (3.7–5.7)
	First 48 h	4.2 (3.5–4.6)	4.0 (3.8–6.1)	4.3 (3.6–4.9)
Omeprazole	First 24 h	3.9 (2.6–4.7)	5.8 (4.3–6.3)^*	6.1 (5.3–7.4)^*
	First 48 h	4.8 (3.2–5.3)	6.0 (5.4–6.5)^*	6.1 (5.7–7.5)^*
Concomitant	First 24 h	4.8 (4.5–5.4)	5.8 (5.1–6.4)^*	5.8 (5.4–6.2)^*
	First 48 h	5.3 (4.7–5.4)	5.7 (5.5–6.4)^*	5.9 (5.5–6.2)^*

^*: 𝑃<0.05 (versus RM).