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Evidence-Based Complementary and Alternative Medicine
Volume 5 (2008), Issue 2, Pages 205-219
http://dx.doi.org/10.1093/ecam/nem016
Original Article

Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers

1Mibyou Medical Research Center, Institute of Preventive Medicine, Tokyo, Japan
2Department of Immunology, School of Medicine, Juntendo University School of Medicine, Tokyo, Japan
3Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
4Department of Acupuncture and Moxibustion, Suzuka University of Medical Science and Mie, Japan
5Toei Pharmaceutical Co., Ltd., Tokyo, Japan

Received 1 July 2006; Accepted 16 January 2007

Copyright © 2008 Ying Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We performed studies on murine models and human volunteers to examine the immunoenhancing effects of the naturally outdoor-cultivated fruit body of Agaricus brasiliensis KA21 (i.e. Agaricus blazei). Antitumor, leukocyte-enhancing, hepatopathy-alleviating and endotoxin shock-alleviating effects were found in mice. In the human study, percentage body fat, percentage visceral fat, blood cholesterol level and blood glucose level were decreased, and natural killer cell activity was increased. Taken together, the results strongly suggest that the A. brasiliensis fruit body is useful as a health-promoting food.