Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats

Table 2

Effect of TAA, Silymarin, and O. stamineus ethanolic extract on biochemical parameters in thioacetamide-Induced liver cirrhosis rats.

Animal group	ALT (IU/L)	AST (IU/L)	ALP (IU/L)	Bilirubin (mg/dl)	T.Protein (g/l)	Albumin (g/l)	MDA nmol/mL
Normal control	64.9 ± 4.19^a	164.4 ± 10.74^a	109.6 ± 9.80^a	1.86 ± 0.1^a	74.3 ± 1.15^a	12.1 ± 0.51^a	38.7 ± 2.6^a
TAA Control	213.3 ± 25.98^d	372.6 ± 29.98^d	435.8 ± 29.78^d	8.7 ± 0.57^d	60.7 ± 0.97^d	8.3 ± 0.57^d	107.1 ± 3.7^d
HD 200 mg/kg	95.7 ± 9.35^b	228.6 ± 14.10^b	289.0 ± 14.23^c	4.8 ± 0.59^b	68.0 ± 2.06^c	11.1 ± 0.63^c	45.3 ± 3.5^b
LD 100 mg/kg	108.0 ± 11.15^c	253.4 ± 18.67^c	383.6 ± 20.89	6.4 ± 0.72^c	64.6 ± 1.29	9.3 ± 0.36	72.6 ± 3.9^c
Silymarin 50 mg/kg	70.4 ± 5.60^b	171.6 ± 10.19^b	139.4 ± 9.54^b	3.0 ± 0.31^b	70.9 ± 0.91^b	11.7 ± 0.68^b	40.3 ± 2.8^b

All values are expressed as mean ± S.E.M. of eight rats in each group. Values not sharing a common superscript differ significantly, *𝑃<.05. ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase, and MDA: malondialdehyde.