Biphasic Effect of Phyllanthus emblica L. Extract on NSAID-Induced Ulcer: An Antioxidative Trail Weaved with Immunomodulatory Effect

Table 3

eAE on MPO activity.

Groups	MPO activity (U/mg) days of ulceration
	1	2	3	4	7
Sham treated	0.0153±0.003	0.0143 ± 0.005	0.0217 ± 0.003	0.021 ± 0.004	0.0224 ± 0.004
Ulcerated untreated	1.1454^∗,b,f,g±0.074	1.8849^∗,b,f,ggg ± 0.061	2.7606^∗,bb,ff,ggg ± 0.047	2.6111^∗,bb,ff,gg ± 0.18	1.7655^∗,bb,ff,g ± 0.164e
eAE (120 mg/kg)	1.2417 ± 0.049	1.9407 ± 0.039	3.7863 ± 0.334	3.783 ± 0.313	3.6187 ± 0.042
eAE (100 mg/kg)	1.0868 ± 0.047	1.8523 ± 0.079	3.8357 ± 0.049	3.77 ± 0.119	2.9305 ± 0.036
eAE (80 mg/kg)	1.0825 ± 0.052	1.5424 ± 0.056	2.1369 ± 0.097	2.0766 ± 0.045	1.817 ± 0.045
eAE (70 mg/kg)	1.0079 ± 0.005	1.2408 ± 0.048	1.92 ± 0.031	1.853 ± 0.033	1.166 ± 0.047
eAE (60 mg/kg)	0.7585^aaa,bb ± 0.031	1.0599^aaa,bb ±0.008	1.5363^aaa,bb ± 0.027	1.45^aaa,bb ± 0.053	0.8439^aaa,bb ± 0.038
eAE (50 mg/kg)	1.0223^aa ± 0.006	1.6236^aaa± 0.017	2.3861^aa ± 0.009	2.3069^a ± 0.009	1.5302^aa ± 0.051
eAE (40 mg/kg)	1.0623^a ±0.038	1.5827^aaa± 0.047	2.7629^a ± 0.015	2.7488^a ± 0.036	1.8709^a ± 0.081
Omeprazole(3 mg/kg)	1.0285 ± 0.008	1.3929 ± 0.009	1.9145 ± 0.029	1.755 ± 0.062	1.0359 ± 0.014

The values are mean (𝑛=8) and (±) indicates S.D. ^∗𝑃<.001 when compared to the Sham Treated;^a𝑃>.05, ^aa𝑃<.05, ^aaa𝑃<.001 when compared to ulcerated untreated;^b𝑃>.05, ^bb𝑃<.001 whencompared to eAE (120 mg/kg);^f𝑃>.05, ^ff𝑃<.001 when compared to eAE (100 mg/kg);^g𝑃>.05, ^gg𝑃<.05, ^ggg𝑃<.001 when compared to eAE (80 mg/kg) treated group.