Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation
Figure 6
GL protects against MPP+-induced reduction of [3H] DA uptake in MES 23.5 cell cultures with or without microglia. The cultures were treated with vehicle or 100 M MPP+, and 400 g/ml GL. GL was given 30 min before the MPP+ exposure. Uptake of [3H] DA was assessed as described in Methods section. Data were generated from cell samples in duplicated experiments, and are expressed as percent of the vehicle group. * compared with corresponding MES 23.5 in the absence or presence of microglia cultures without exposure to MPP+; ** compared with the MPP+-treated MES 23.5 cultures without microglia; # compared with corresponding MES23.5 in the absence or presence of microglia cultures without exposure to GL.
