Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation
Figure 7
GL protects against LPS-induced reduction of [3H] DA uptake in MES 23.5 cell cultures with or without microglia. The cultures were treated with vehicle or 0.25 g/ml LPS, and 400 g/ml GL. GL was given 30 min before the LPS exposure. Uptake of [3H] DA was assessed as described in Methods section. Data were generated from cell samples in duplicated experiments, and are expressed as percent of the vehicle group. * compared with corresponding MES 23.5 in the absence or presence of microglia cultures without exposure to LPS; # compared with corresponding MES 23.5 and microglia co-cultures without exposure to GL.
