Increased Survivorship and Altered Cytokine Profile from Treatment of Influenza A H1N1-Infected Mice with Ekybion: A Drug Complex of Natural Extracts and Inorganic Compounds
Figure 3
Effects of Ekybion on influenza A infection in Balb/c mice. Female Balb/c mice were infected with 5 influenza A/PR/8/34 H1N1 and treated every 8 hours for 10 days beginning at indicated times and doses. Mice were weighed daily (data not shown), and monitored for survival for 16 days (a). On day 2 postinfection, 2–5 mice per group were euthanized for determination of virus titer in lungs by plaque assay (b). There were no significant differences in weight loss or lung pathology between any groups. However, there was a dose-dependant antiviral response with significant reduction in virus titer seen in the 10X group ( by one-way ANOVA with Dunnett’s posttest). Survival in the 1X 2 min group was also significantly improved ( by log-rank (Mantel-Cox) test and Gehan-Breslow-Wilcoxon test).
