Increased Survivorship and Altered Cytokine Profile from Treatment of Influenza A H1N1-Infected Mice with Ekybion: A Drug Complex of Natural Extracts and Inorganic Compounds
Figure 5
Theoretical mechanism of action and method for improved efficacy. (a) The current composition of Ekybion contains plant extracts known to have antiviral and immunomodulatory potential. The beneficial and negative interplay between these two effects is shown here where mild inhibition of inflammation (resulting in relief of some symptoms associated with influenza infection) is beneficial but overt inhibition of inflammation (impaired tissue repair or viral clearance late in infection) is detrimentla to disease resolution. Conversely, increasing inhibition of virus replication is beneficial. (b) In order to maximize the therapeutic benefit obtained from Ekybion we propose optimizing the concentrations of the 16 components to increase the antiviral properties and limit the immunomodulatory effects.
