Review Article

Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds

Table 1

Chemical constituents and their reported activities of A. camphorata.

No.Compound nameSourceBiological activityRef.

Terpenoids
1AntrocinF[19]
219-Hydroxylabda-8(17)-en-16,15-olideFIn vitro neuroprotective[28]
33β,19-Dihydroxylabda-8(17),11E-dien-16,15-olideFIn vitro neuroprotective[28]
413-epi-3β,19-Dihydroxylabda-8(17),11E-dien-16,15-olideFIn vitro neuroprotective[28]
519-Hydroxylabda-8(17),13-dien-16,15-olideFIn vitro neuroprotective[28]
614-Deoxy-11,12- didehydroandrographolideFIn vitro neuroprotective[28]
714-DeoxyandrographolideF[28]
8Pinusolidic acidF[28]
9Antcin AFIn vitro anti-inflammatory, anti-insecticidal and cytotoxic[30, 64, 65]
10Antcin B (Zhankuic acid A)FIn vitro anti-inflammatory, anti-insecticidal and cytotoxic[18, 30, 6466]
11Antcin CFIn vitro anti-inflammatory and cytotoxic[65, 67]
12Antcin D (Zhankuic acid F)F[23]
13Antcin EF[21]
14Antcin FF[21]
15Antcin GF[21]
16Antcin H (Zhankuic acid C)FIn vitro anti-inflammatory, anti-insecticidal and cytotoxic[18, 6466]
17Antcin I (Zhankuic acid B)FIn vitro anti-inflammatory[66]
18Antcin KFIn vitro anti-inflammatory[66]
19Methyl antcinate AF[25]
20Methyl antcinate BFIn vitro anti-insecticidal and cytotoxic[64, 65]
21Zhankuic acid DF[25]
22Methyl antcinate GF[21]
23Methyl antcinate HF[21]
24Zhankuic acid EF
25Dehydroeburicoic acidFIn vitro anti-inflammatory, anti-insecticidal[64, 65, 67]
26Dehydrosulphurenic acidFIn vitro anti-insecticidal and cytotoxic[64, 65]
2715α-Acetyl-dehydrosulphurenic acidFIn vitro anti-insecticidal and cytotoxic[64, 65]
28Eburicoic acidFIn vitro anti-insecticidal and cytotoxic[64, 65]
29Sulphurenic acidFIn vitro anti-insecticidal and cytotoxic[64, 65]
30Versisponic acid DF
31Eburicol (24-methylenedihydrolanosterol)FIn vitro anti-inflammatory[30]
323β, 15α-Dihydroxy lanosta-7,9(11),24-triene-21-oic acidFIn vitro anti-insecticidal and cytotoxic[64, 65]
333β-Hydroxy lanosta-F[17]
34β-SitosterolF[28]
35β-SitostenoneF[28]
36StigmasterolF[28]
37ErgosterolF[28]
38Ergosta-4,6,8(14)22-tetraen-3-on3F[30]
39epi-FriedelinolF[30]
Benzenoids
401,4-Dimethoxy-2,3-methylenedioxy-5-methylbenzeneFIn vitro cytotoxic[68]
411,4-Dimethoxy-2,3-methylenedioxy-5-benzoateF[24]
421,6-Dimethoxy-2,3-methylenedioxy-4-benzoic acidF[24]
43Antrocamphin AFIn vitro anti-inflammatory[30]
44Antrocamphin BF[30]
452,3,4,5-Tetramethoxybenzoyl chlorideF[30]
46AntrodioxolanoneF[30]
47Isobutylphenol[34]
Lignans
48(+) SesaminF[20]
494-Hydroxy sesaminF[20]
50( ) SesaminF[20]
Benzoquinone derivatives
515-Methyl-benzo(1,3)-dioxole-4,7-dioneM[20]
522-Methoxy-5-methyl(1,4)benzoquinoneMIn vitro anti-oxidant[20]
532,3-Dimethoxy-5-methyl(1,4)benzoquinoneMIn vitro anti-inflammatory[20, 30]
Succinic and Maleic derivatives
54trans-3-Isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dioneFIn vitro anti-inflammatory[33]
55trans-1-Hydroxy-3-(4-hydoxyphenyl)-4-isobutylpyrrolidine-2,5-dioneFIn vitro anti-inflammatory[33]
563R*,4S*-1-Hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione (antrodin D or Camphorataimide E)F, MIn vitro anti-inflammatory, anti-HBV and anti-HCV[29, 33, 69]
57cis-3-(4-Hydroxyphenyl)-4-isobutyldihydrofuran-2,5-dioneFIn vitro anti-inflammatory[33]
583-(4-Hydroxyphenyl)-4-isobutyl-1H-pyrrole-2,5-dioneFIn vitro anti-inflammatory[33]
593-(4-Hydroxyphenyl)-4-isobutylfuran-2,5-dione (Antrocinnamomin C)FIn vitro anti-inflammatory[33, 35]
603-Isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione (antrodin A or Camphorataanhydride A)MIn vitro anti-HBV and anti-HCV[29, 69]
61Dimethyl 2-(4-hydroxyphenyl)-3-isobutylmaleateFIn vitro anti-inflammatory[33]
623-Isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrole-2,5-dione (Antrodin B or Camphorataimide B)M, BIn vitro anti-inflammatory, anti-HBV and anti-HCV[26, 29, 69]
63Antrocinnamomin DM[35]
643-Isobutyl-4-[4-(3-methyl-2-nyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione (antrodin C or) Camphorataimide C)MIn vitro anti-inflammatory, anti-HBV and anti-HCV[28, 31, 70]
65Antrocinnamomins AMIn vitro anti-inflammatory[37]
663R*,4R*-1-Hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione (Antrodin E or Camphorataimide D)MIn vitro anti-HBV and anti-HCV[31, 70]
67Antrocinnamomins BMIn vitro anti-inflammatory[37]
Miscellaneous compounds
682,2′,5,5′-Tetramethoxy-3,4,3′,4′-bi-methylenedioxy-6,6′-dimethylbiphenylFIn vitro anti-HBV[71]
69α-Tocospiro BF[30]
70Methyl oleateF[20]
71AntroquinonolM, FIn vitro cytotoxic, anti-inflammatory, anti-HBV[12, 32, 72]
72AdenosineMPrevention of PC 12 cells apoptosis[37]
73CordycepinM[37]
742,4,5-trimethoxybenzaldehydeMPrevention of PC 12 cells apoptosis[31]
75Antroquinonol BMIn vitro anti-inflammatory[36]
764-acetyl-antroquinonol BMIn vitro anti-inflammatory[36]
772,3-(methylenedioxy)-6-methylbenzene-1,4-diolMIn vitro anti-inflammatory[36]
782,4-dimethoxy-6-methylbenzene-1,3-diolMIn vitro anti-inflammatory[36]

F: Fruiting bodies; M: Mycelium; B: Culture broth.