Resequencing DCDC5 in the Flanking Region of an LD-SNP Derived from a Kidney-Yang Deficiency Syndrome Family

Table 2

Five SNPs of linkage disequilibrium derived from a KDS family. A conventional approach, lod adds Score method (LODs), was employed to calculate the levels of recombination condition. The LOD values (or Z value) were reckoned at different 𝜃 values (𝜃=0∼0.5). The criteria standard of linkage are, 𝑍>1: support linkage, 𝑍>3: linkage. Accordingly, 𝜃≤0.10 indicates tight linkage, 0.10<𝜃<0.20, midrange linkage, 𝜃≥0.20, loose linkage.

SNP NO.	SNP1	SNP2	SNP3	SNP4	SNP5
RefSNP ID	rs514207	rs1054020	rs7685923	rs10515889	rs10516202
Physical position	11:−31035695	5:145505341	4:10758418	5:164479475	4:9802214
LOD (theta = 0.0)	2.018	2.105	2.141	2.007	2.03
LOD (theta = 0.05)	1.801	1.882	1.917	1.791	1.815
LOD (theta = 0.1)	1.578	1.651	1.686	1.568	1.596
LOD (theta = 0.2)	1.114	1.167	1.206	1.108	1.149
LOD (theta = 0.3)	0.641	0.669	0.71	0.642	0.691
LOD (theta = 0.4)	0.206	0.225	0.239	0.226	0.248
Referred gene	DCDC5	LARS	/	/	/