The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT3 Receptor Pathway in Rats
Figure 2
Changes in gastric emptying by 5-HT, 5-HT3, 1-(3-chlorophenyl) biguanide, and 5-HT4 (mosapride) agonists in rats: intraperitoneal injection of 5-HT (0.1 and 1.0 mg kg−1) significantly delayed gastric emptying compared with the controls (from 81.7 ± 4.5 to 50.2 ± 8.8 and 38.5 ± 4.3%) in a dose-dependent manner. The 5-HT3 agonist 1-(3-chlorophenyl) biguanide significantly delayed gastric emptying, similar to 5-HT (from 78.8 ± 3.1 to 40.2 ± 6.4%), whereas the 5-HT4 agonist mosapride (0.3–3.0 mg kg−1) accelerated it (from 75.6 ± 5.7 to 90.7 ± 2.3%). Each column represents the mean ± SEM. of eight rats. *P < .01: significantly different from the control group.
