The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT3 Receptor Pathway in Rats
Figure 4
Improvement in the 5-HT3 agonist [1-(3-chlorophenyl) biguanide]-induced delay in gastric emptying by rikkunshito (a) and ondansetron (b): the delay induced by intraperitoneal injection of the 5-HT3 agonist 1-(3-Chlorophenyl) biguanide at 0.4 mg kg−1 (from ~80 to 35–40%) was suppressed by rikkunshito administration in a dose-dependent manner (a). Like rikkunshito, pretreatment with ondansetron significantly ameliorated delay of gastric emptying in a dose-dependent manner (b). Each column represents the mean ± SEM of eight rats. **P < .01, *P < .05: significantly different from the control group.
