The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT3 Receptor Pathway in Rats
Figure 5
Improvement in the 5-HT-induced delay in gastric emptying by hesperidin: administration of hesperidin (one of the ingredients extracted from rikkunshito) improved the 5-HT-induced delay in gastric emptying in a dose-dependent manner. Hesperidin at a high dose (3.0 mg kg−1) showed a similar effect to that of ondansetron (0.4 mg kg−1) for this delay, but hesperidin at a lower dose (0.3 or 1.0 mg kg−1) did not. Each column represents the mean ± SEM of eight rats. **P < .05: significantly different from the control group.
