Suppressive Effect on Lipopolysaccharide-Induced Proinflammatory Mediators by Citrus aurantium L. in Macrophage RAW 264.7 Cells via NF-B Signal Pathway
Figure 1
Main molecular targets of CME that lead to inhibitory effects on LPS-induced inflammation action. CME blocking NF-B signaling pathway via inhibition of (i) IκB phosphorylation, (ii) subunits (p65/p50) of NF-B trnaslocation in nuclear, and (iii) proinflammatory mediators (COX-2, iNOS, etc.) transcription. Blue arrows indicate the NF-κB signal pathway and target gene that DNA binding site of NF-B. Red boxes indicate the inhibition effect of CME. CME: Crude methanol extract of Citrus aurantium L.; IKK: IB kinase; IB: Inhibitor of B in cytoplasm; p50/p65: subunits of NF-B; COX-2: cyclooxygenase-2; iNOS: inducible nitric oxide synthase.
