Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract: Role of Gallic Acid and Cinnamic Acid in H+, K+-ATPase/H. pylori Inhibition and Anti-Oxidative Mechanism
Figure 2
Effect of GRAE on H. pylori growth. Anti-H. pylori activity was tested by the standard agar diffusion method (a). A 5.5 mm discs containing 10 μg each of Amoxicillin-a known antibiotic (a.2); GRAE were impregnated with agar and (a.1) served as control with no inhibitor disc. Clear area around the disc represents the inhibition zone due to the effect of the test fraction. (b)–(f) indicate the scanning electron microscopic pictures at 15 k magnification of control (b), amoxicillin (c), GRAE (d) treated H. pylori and (e) and (f) depicts the H. pylori treated with pure phenolic acids gallic and cinnamic acid respectively. Untreated control cultures indicate uniform rod shaped H. pylori cells. Amoxicillin treatment showed coccoid form, blebbing, fragmented and lysed cells. Similar altered conditions observed in GRAE and pure phenolics treated H. pylori cells. were taken from our previous paper [14] for the comparative purpose.
