CI431, an Aqueous Compound from Ciona intestinalis L., Induces Apoptosis through a Mitochondria-Mediated Pathway in Human Hepatocellular Carcinoma Cells

Figure 2

CI431 inhibited the growth of several types of cancer cells. Human hepatoma BEL-7402, human colon cancer HCT116, human breast cancer MCF-7, human cervical cancer Hela cells, and human lung adenocarcinoma A549 as well as human benign liver cell BEL-7702 cells were incubated in the absence or presence of certain concentrations of CI431 for 48 h at 37°C. MTT assay was performed to determine the growth inhibition of different cancer cells and benign BEL-7702 cells by CI431. The experiments were performed more than three times.