Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents
Table 4
Effect of a forty-day oral administration of Corrigiola telephiifolia extract on hematological parameters of Wistar rats.
Corrigiola telephiifolia (mg/kg/day)
Control
5
70
2000
Females
Parameter
WBC (103/mm3)
6.2 ± 0.6
6.0 ± 0.5
5.9 ± 0.5
5.9 ± 0.9
RBC (106/mm3)
6.2 ± 0.4
6.2 ± 0.3
6.5 ± 0.4
6.2 ± 0.3
HGB (g/dL)
10.7 ± 0.7
10.8 ± 0.6
11.2 ± 0.6
10.3 ± 0.4
HCT (%)
33.3 ± 2.3
33.5 ± 2.3
35.2 ± 2.3
32.2 ± 1.6
PLT (103/mm3)
143.0 ± 13.5
145.0 ± 15.1
151.7 ± 19.5
146.4 ± 14.2
MCV (m3)
54.2 ± 1.0
54.2 ± 0.9
54.3 ± 0.6
52.1 ± 0.4
MCH (pg)
17.4 ± 0.3
17.4 ± 0.2
17.3 ± 0.15
16.6 ± 0.3
MCHC (g/dL)
32.1 ± 0.2
32.0 ± 0.3
32.0 ± 0.3
32.0 ± 0.3
RDW (%)
13.2 ± 0.3
13.3 ± 0.3
13.3 ± 0.2
13.7 ± 0.3
MPV (m3)
9.1 ± 0.8
9.2 ± 0.5
10.2 ± 0.5
9.3 ± 1.0
Males
WBC (103/mm3)
7.4 ± 1.5
6.8 ± 0.9
6.4 ± 0.7
6.8 ± 0.9
RBC (106/mm3)
6.6 ± 0.3
6.5 ± 0.4
6.4 ± 1.0
7.8 ± 0.9
HGB (g/dL)
10.8 ± 0.4
10.7 ± 0.8
10.3 ± 1.5
12.2 ± 1.1
HCT (%)
34.9 ± 1.5
34.5 ± 1.9
32.9 ± 5.4
41.1 ± 4.9
PLT (103/mm3)
158.2 ± 11.3
149.4 ± 13.2
124.8 ± 14.6
136.2 ± 19.2
MCV (m3)
53.2 ± 0.7
52.3 ± 0.6
51.6 ± 0.8
52.8 ± 0.6
MCH (pg)
16.5 ± 0.2
16.2 ± 0.2
16.2 ± 0.3
15.8 ± 0.4
MCHC (g/dL)
31.0 ± 0.4
31.2 ± 0.5
31.6 ± 0.7
30.1 ± 0.8
RDW (%)
14.0 ± 0.7
13.7 ± 0.4
13.6 ± 0.3
13.8 ± 0.4
MPV (m3)
7.0 ± 1.5
7.2 ± 0.5
7.5 ± 0.4
8.1 ± 0.4
C. telephiifolia extract was administered daily for 40 consecutive days to rats Data are expressed as mean ± S.E.M. There were no statistically significant differences between control and treated groups.
