Research Article
Evaluation of the Anxiolytic Activity of NR-ANX-C (a Polyherbal Formulation) in Ethanol Withdrawal-Induced Anxiety Behavior in Rats
Table 5
Chronic NR-ANX-C pretreatment reduced EW-induced anxiety behavior in elevated plus maze.
| Treatment group | Number of entries into | Total Arm entries | % of open/total arm entries | Time spent in (s) | Number of rears in |
| | Open arms | Closed arms | | | Open arms | Closed arms | Open arms | Closed arms |
| EW control | 1.6 ± 0.4 | 5.7 ± 0.8 | 7.4 ± 1.1 | 19.8 ± 5.1 | 15.1 ± 5.7 | 277.0 ± 5.0 | 1.1 ± 0.4 | 10.6 ± 1.3 | Alprazolam (0.08 mg/kg) | 3.8 ± 0.5* | 4.8 ± 0.9 | 8.7 ± 1.1 | 45.7 ± 4.2* | 54.7 ± 15.1* | 234.0 ± 15.1* | 3.7 ± 0.6* | 16.2 ± 1.5* | NR-ANX-C (10 mg/kg) | 3.8 ± 0.7* | 4.8 ± 0.8 | 8.7 ± 1.3 | 44.8 ± 4.2* | 32.2 ± 3.4 | 262.0 ± 3.8 | 3.0 ± 0.7 | 10.8 ± 1.7 | NR-ANX-C (20 mg/kg) | 4.5 ± 0.6* | 4.2 ± 0.8 | 8.7 ± 0.3 | 53.1 ± 7.9* | 45.0 ± 10.0* | 245.0 ± 5.7* | 3.8 ± 0.8* | 11.2 ± 0.9 | NR-ANX-C (40 mg/kg) | 4.8 ± 0.3* | 4.3 ± 0.7 | 9.1 ± 0.9 | 52.74 ± 5.6* | 49.7 ± 11.1* | 242.0 ± 16.2* | 4.8 ±1.1* | 19.5 ± 0.6* |
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Values are mean ± SEM; Statistical analysis by One-way ANOVA followed by Dunnett’s Multiple Comparison test. ; .
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