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Reference | Country | Patients (I/C)* | Inclusion criteria | C/A** | Gender (m/f in %) | Age range (years) | Treatment | Treatment (days) |
Intervention group | daily dose | Control group | daily dose |
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Randomized controlled trials (RCTs) |
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Kemmerich et al. 2006 | Germany | 182/178 | Acute bronchitis | A | 46.7/53.3 | 18–87 y | Ivy + Thyme, “Bronchipret” syrup Ivy: 1.5 g LE/100 g (1:1, E70%) Thyme: 15 g LE/100 g (1:2–2.5) | 16.2 ml | Placebo | n.a. | 10 |
Unkauf and Friedrich 2000 | Germany | 25/27 | Acute bronchitis | C | 51.9/48.1 | <12 y | Ivy, “Valverde” syrup 0.33–0.5 g DE/100 ml (3–6:1, E60%) | 10–20 ml | Ivy, “Prospan” syrup 0.7 g DE/100 ml (5–7.5:1, E30%) | 10–20 ml | 10 |
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Controlled trials (CCTs) |
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Bolbot et al. 2004 | Ukraine | 25/25 | Acute bronchitis | C | 64.0/36.0 | 2–10 y | Ivy, “Prospan” syrup (5–7.5:1) | 15–30 ml | Acetylcysteine | 300–1200 mg | 7–10 |
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Observational studies (OSs) |
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Büechi and Kähler 2003 | Switzerland | 56 | Acute bronchitis, common cold | C/A | 32.1/67.9 | 7–93 y | Ivy, pastilles 26 mg DE/pastille (4–8:1, E30%) | 2–6 pastilles, 52–156 mg DE | | | 7 |
Büechi et al. 2005 | Switzerland | 62 | Acute and chronic bronchitis, common cold | A | 40.3/59.7 | 16–89 y | Ivy + Thyme, syrup, Ivy: 1.0 g DE/100 g (4–8:1, E30%) Thyme: 25.4 g DE/100 g (1:3.5–4) | 5–15 ml (6.7–20.1g) | | | 3–23 |
Fazio et al. 2009 | Latin America*** | 9657 | Acute and chronic bronchitis, cough | C/A | NR | 0–98 y | Ivy, syrup (5–7.5:1, E30%) | 7.5–22.5 ml | | | 7 |
Hecker 1999 | Germany | 248 | Bronchitis | C/A | 44.4/55.6 | 0–70 y | Ivy, “Prospan” syrup in 48.4% of patients, “Prospan” effervescent tablets in 51.6% of patients | NR | n.a. | ~8 (mean) |
Leskow 1985 | Germany | 84 | Acute and chronic bronchitis, chesty cough, pertussis | C/A | 46.4/53.6 | 1–82 y | Ivy, “Prospan” drops 2 g DE/100 ml | 30–100 drops | | | 12.3 (mean) |
Marzian 2007 | Germany | 1044 | Acute bronchitis | C | 50.5/49.5 | 0–17 y | Ivy + Thyme, “Bronchipret” syrup Ivy: 1.5 g LE/100 g (1:1, E70%) Thyme: 15 g LE/100 g (1:2–2.5) | 9.6–16.2 ml | | | 10 |
Santoro Júnior 2005 | Brasil | 5850 | Bronchitis | C/A | 47.9/52.1 | NR | Ivy, “Abrilar” syrup | 7.5–22.5 ml | | | 7 |
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