Research Article

Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [3H]Glutamate Binding to Rat Synaptic Membranes

Figure 1

Effects of different valerian, valerenic acid, and isoborneol concentrations on [3H]Glutamate binding. Synaptic membranes were incubated with different concentrations of aqueous valerian extract, valerenic acid, and isoborneol in presence of 20 nM [3H]Glutamate. The maximum glutamate binding was 160% for valerian extract concentration of 0.001 mg/mL. The [3H]Glutamate displacement curves in presence of valerenic acid and isoborneol were very different from the curve in presence of valerian. Each point represents at least three independent assays.
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