Analgesic Effects and the Mechanisms of Anti-Inflammation of Hispolon in Mice
Figure 8
Histological appearance of the mouse hind footpad after a subcutaneous injection with 0.9% saline (control group) or carrageenan (Carr) stained with H&E stain. (a). Control rats: show the normal appearance of dermis and subdermis without any significantly lesion. (b). Hemorrhage with moderately extravascular red blood cell and large amount of inflammatory leukocyte mainly neutrophils infiltration in the subdermis interstitial tissue of mice following the subcutaneous injection of Carr only. Moreover, detail of the subdermis layer show enlargement of the interstitial space caused by edema with exudates fluid. (c). Indomethacin (Indo) significantly reduced the level of hemorrhage, edema and inflammatory cell infiltration compared to subcutaneous injection of Carr only. (d). Hispolon significantly show morphological alterations compared to subcutaneous injection of Carr only. (100x) (e). The numbers of neutrophils were counted in each scope (400x) and thereafter obtain their average count from five scopes of every tissue slice. **P < .01, compared with Carr group.
