Original Article

Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation

Table 1

Alterations in gene expression in DNP-KLH immunized BALB/c mice that were treated with EA stimulation.

GenesSymbol Regulation profile and average fold change
NC versus HoldHold versus EA

Cluster 3
T-cell receptor alpha variable region family 13 subfamily 1Tcra-V13.1 0.350.88
Limb expression 1 homolog (chicken)Lix1 0.110.3
Trefoil factor 2 (spasmolytic protein 1)Tff2 0.120.31
Heat shock protein 1BHspa1b 0.080.38
Olfactory receptor 1436Olfr1436 0.230.55
Olfactory receptor 1475Olfr1475 0.431.15
2′–5′ oligoadenylate synthetase 1FOas1f 0.230.34
Olfactory receptor 689Olfr689 0.130.35
Olfactory receptor 26Olfr26 0.100.39
ProbasinPbsn 0.440.80
Cluster 5
DermatopontinDpt0.15 0.29
Decay accelerating factor 2Daf20.17 0.30
Anterior gradient homolog 3 (Xenopus laevis)Agr30.13 0.35
Secretagogin, EF-hand calcium binding proteinScgn0.36 0.35
3-oxoacyl-ACP synthase, mitochondrialOxsm0.22 0.32
Empty spiracles homolog 2 (Drosophila)Emx20.48 0.45
Aldehyde dehydrogenase 3 family, member B1Aldh3b10.22 0.38
Cytochrome P450, family 2, subfamily c, polypeptide 38Cyp2c380.27 0.79
Sulfide quinone reductase-like (yeast)Sqrdl0.20 0.28
Olfactory receptor 1231Olfr12310.27 0.35
Myosin light chain 2, precursor lymphocyte-specificMylc2pl0.13 0.26
NLR family, pyrin domain containing 4ENlrp4e2.32 3.96
Olfactory receptor 617Olfr6170.21 0.37
Olfactory receptor 544Olfr5440.29 0.37
Carboxylesterase 2Ces20.09 0.28
NAD(P)H dehydrogenase, quinone 1Nqo10.17 0.28
Sodium channel, voltage-gated, type X, alphaScn10a0.17 0.45
Cluster 6
Olfactory receptor 1393Olfr1393 0.1 0.47
Insulin-like growth factor 2 mRNA binding protein 1Igf2bp10.05 0.29
Cathepsin 3Cts30.06 0.39
Olfactory receptor 720Olfr720 0.19 0.27
Cell division cycle 25 homolog C (S. pombe)Cdc25c0.05 0.27
Programmed cell death 1 ligand 2Pdcd1lg20.05 0.34
Olfactory receptor 1310Olfr13100.03 0.55
Group specific componentGc 0.02 0.32
G protein-coupled receptor, family C, group 5, member DGprc5d 0.07 0.37
Serum amyloid A 4Saa4 0.51 0.53
Vomeronasal 2, receptor 65Vmn2r650.05 0.53
Intestine specific homeoboxIsx0.05 0.29