Evidence-Based Complementary and Alternative Medicine / 2011 / Article / Tab 3 / Review Article
Traditional Japanese Kampo Medicine: Clinical Research between Modernity and Traditional Medicine—The State of Research and Methodological Suggestions for the Future Table 3 Kampo clinical studies comparing Kampo with placebo.
Author (Year) (
) Reference Language ICD 10 code (disease name) Design Cases (
) Randomization Blinding Groups (
) Intervention Control Kampo treatment Suzuki et al. (2002) [54 ] J A49.0 (MRSA) RCT 13 R DB 2 K P hochuekkito Hioki et al. (2004) [55 ] E E66.9 (obesity) RCT 81 R DB 2 K P bofutsushosan Suzuki et al.(2005) [56 ] E F03 (dementia) RCT 30 R DB 3 K P goshajinkigan, chotosan Iwasaki et al. (2004) [57 ] E F03 (dementia) RCT 33 R DB 2 K P hachimijiogan Nagaki et al. (2003) [58 ] E H16.1 (keratitis) RCT 75 R DB 3 K P goshajinkigan Arakawa et al. (2006) [59 ] E I10 (essential hypertension) RCT 204 R DB 2 K P orengedokuto Nakamura et al. (2000) [60 ] J I95.1 (Orthostatic hypotension) RCT-cross over 10 R SB 2 K P goreisan Kaji et al. (2001) [61 ] J J00 (acute nasopharyngitis) RCT 250 R DB 2 K P shosaikoto Baba (1995) [62 ] J J30.4 (allergic rhinitis) RCT 217 E DB 2 K P shoseiryuto Miyamoto et al. (2001) [63 ] J J40 (bronchitis) RCT 192 R DB 2 K P shoseiryuto Urata et al. (2002) [64 ] E J45.0 (bronchial asthma) RCT-cross over 33 R DB 2 K P saibokuto Nishizawa et al. (2001) [65 ] J J45.0 (bronchial asthma) RCT 32 R DB 2 K P Saibokuto inhalation Nishizawa et al. (2001) [66 ] J J45.0 (bronchial asthma) RCT 74 R DB 2 K P Saibokuto inhalation Iwasaki et al. (2007) [67 ] E J69.0 (pneumonitis) RCT 95 R DB 2 K P hangenkoubokuto Harasawa et al. (1998) [68 ] J K31.9 (dysmotility-like dyspepsia) RCT 296 R DB 2 K P rikkunshito Sasaki et al. (1998) [69 ] J K58 (irritable bowel syndrome) RCT 204 E DB 2 K P keishikashakuyakuto Miyoshi et al. (1994) [70 ] J K59.0 (constipation) RCT 146 E DB 3 K P daiokanzoto Itoh et al. (2002) [71 ] E K91.3 (post-operative ileus) RCT 24 R SB 2 K P daikenchuto Takagaki et al. (2000) [72 ] J K91.3 (paralytic ileus) RCT 21 R SB 2 K P daikenchuto
Nishizawa et al. (2004) [73 ] E/J M35.0 (Sicca syndrome) RCT 229 R DB 2 K P bakumondoto Aoki et al. (2001) [74 ] E N39.9 (urodynamic studies) RCT-cross over 19 R SB 2 K P maobushisaishinto Kumada et al. (1999) [75 ] J R25.2 (muscle cramps) RCT 126 R DB 2 K P shakuyakukanzoto Odaguchi et al. (2006) [76 ] E/J R51 (headache) RCT 53 R DB 2 K P goshuyuto Satoh et al. (2005) [77 ] E R54 (senile muscle weekness) RCT 13 R DB 3 K P hochuekkito Hamazaki et al. (2007) [78 ] E Z01.8 (adjuvant effect to vaccination) RCT 36 R DB 2 K P hochuekkito Takahashi et al. (2007) [79 ] E Z01.8 (serum amino acid concentration) RCT-cross over 18 R SB 3 K P rokumigan Saruwatari et al. (2004) [80 ] E Z01.8 (COPD) RCT-cross over 26 R DB 2 K P bakumondoto Isobe et al. (2003) [81 ] E Z01.9 (retinal blood flow) RCT-cross over 12 R DB 2 K P hachimijiogan
J: Japanese; E: English; R: randomization; E: envelops; DB: double blind; SB: single blind; K: Kampo; SK: Standard + Kampo; S: Standard; NT: no treatment; P: placebo; ICD: International Classification of Diseases, Kampo treatment includes only formulae produced after 1986, ICD codes details http://apps.who.int/classifications/apps/icd/icd10online/ , dosage of the Kampo formulae http://www.jsom.or.jp/medical/ebm/index.html .
