Nutritional Composition, Antioxidant Activities, and Antiulcer Potential of Lentinus squarrosulus (Mont.) Mycelia Extract

Table 4

Healing of ethanol-induced ulcers by L. squarrosulus and the levels of IL-1β and NF-κB after 24, 48, and 72 hours of treatment.

Treatment	Duration of treatment; (hour)	Dose; (mg/kg)	Ulcer area; (mm^2)	Inhibition; (%)	IL-1β; (pg/ml)	NF-κB; (ng/ml)
Without treatment	24	—	0±0^a	—	20.6±1.2^a	3.92±0.71^a
Distilled water		—	962±11^b	—	48.9±2.7^b	5.49±0.52^a
L. squarrosulus extract		250	172±3^c	82	65.8±3.2^c	4.51±0.39^a
Cimetidine		50	386±3^d	60	30.8±1.5^d	5.29±0.68^a
Without treatment	48	—	0±0^a	—	20.6±1.2^a	3.92±0.71^a
Distilled water		—	333±7^b	65	39.1±0.7^b	0.98±0.20^b
L. squarrosulus extract		250	95±1^c	90	47.2±1.2^c	0.78±0.34^b
Cimetidine		50	173±16^d	82	29.1±0.8^d	2.35±0.00^ab
Without treatment	72	—	0±0^b	—	20.6±1.2^a	3.92±0.71^a
Distilled water		—	82±3^a	92	37.8±1.3^b	0.78±0.20^b
L. squarrosulus extract		250	0±0^b	100	44.0±1.3^c	0.59±0.00^b
Cimetidine		50	0±0^b	100	28.2±0.7^d	1.57±0.39^b

The group “without treatment” refers to normal control group, “distilled water” refers to ulcer control group, “L. squarrosulus extract” refers to treated group and “cimetidine” refers to positive control group. All values were expressed as mean and ± standard error mean. Means with different superscripts were significantly different (𝑃<.05), Six replicates animals were used. Concentration of extract tested was 250 mg/kg, while cimetidine was 50 mg/kg.