Suppression of Heregulin-<i>β</i>1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation

<table>(a) Chemical structures of resveratrol and pterostilbene. (b) Transactivation of HER2 by heterodimerizing HER3 in response to HRG-<i>β</i>1. HRG-<i>β</i>1-stimulated cell lysates were immunoprecipitated with HER2 or HER3 antibodies, and then immunoblotted for antibodies against phosphotyrosine (PY), HER3 or HER2. HRG: heregulin-<i>β</i>1; IP: immunoprecipitation.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 1

Figure 1: Suppression of Heregulin-<i>β</i>1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation 

Figure 1 | Suppression of Heregulin-β1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation 