Proteomic Analysis of Anti-inflammatory Effects of a Kampo (Japanese Herbal) Medicine “Shoseiryuto (Xiao-Qing-Long-Tang)” on Airway Inflammation in a Mouse Model
Figure 6
Effects of SST and prednisolone on airway hyperreactivity (AHR) in OVA-sensitized mice were measured with plethysmography. Non-sensitized mice were treated with water (closed circle), and OVA-sensitized mice were treated with SST (closed inverted triangle), prednisolone (open inverted triangle) or water (open circle) as described in legend of Figure 2. AHR to aerosolized methacholine (MeCh) was measured in unrestrained conscious mice at 1 h after the final treatment of drug. Mice were placed into the main chamber and were nebulized with PBS or MeCh (3.125, 6.25, 12.5, 25, 50 mg ml−1) for 3 min. Recording of Penh was taken for 5 min after each MeCh nebulization. Each bar represents the mean ± SEM of four mice per group. #, ## and ### versus water/non-sensitized group (Fisher's PLSD test). *, ** and *** versus water/OVA-sensitized group (Dunnett's test).
