Attenuation of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats with a Combination of Chinese Herbs (Tangshen Formula)

Table 2

Biochemical indices of control and Tangshen Formula treated rats at 36 and 56 weeks of age.

	weeks	LETO	OLETF	OLETF + TSF	OLETF + Monopril
Total cholesterol (mmol/L)	36	2.71±0.07	2.51±0.15	2.59±0.08	2.77±0.30
	56	2.00±0.06^**##	4.27±0.36^##	2.21±0.21 **	3.94±0.47
Triglyceride (mmol/L)	36	0.26±0.04 **	1.15±0.12	1.01±0.13	0.71±0.05 *
	56	0.21±0.01 **	1.30±0.26	0.96±0.07	1.07±0.17^#
Total protein (mmol/L)	36	60.30±0.76	58.86±1.08	59.29±1.02	58.14±1.06
	56	70.25±0.99^**##	67.17±1.39^##	73.17±2.04^**##	69.20±1.39^##
Albumin (mmol/L)	36	32.00±0.42	30.86±0.34	30.71±0.52	30.57±0.90
	56	32.06±0.39 *	28.62±0.78^##	31.83±1.25 **	29.26±0.67
Urea nitrogen (mmol/L)	36	8.22±0.26	7.53±0.87	6.97±0.50	8.52±0.50
	56	5.28±0.17^**##	7.86±1.02	6.60±0.58	8.07±1.12
Creatinine (μmol/L)	36	89.22±3.29 **	68.00±1.89	68.57±1.19	70.86±1.47
	56	69.75±0.44^**##	58.73±3.01^##	53.18±1.69^##	55.04±2.60^##

Data represent mean ± SEM, *𝑃<.05, **𝑃<.01 versus control OLETF rats; ^#𝑃<.05, ^#𝑃<.01 compares the 36 and 56 weeks of age data groups.