Administration of Chinpi, a Component of the Herbal Medicine Ninjin-Youei-To, Reverses Age-Induced Demyelination

Figure 6

Diagram of the proposed pathways by which hesperidin and naririutin, which are active ingredients of Chinpi, stimulate the FcRγ/Fyn signaling cascade involved in remyelination. The activation of FcRγ/Fyn results in the upregulation of phospho-21.5 kDa MBP and the dramatic morphological differentiation of OPCs. OPC, oligodendrocyte precursor cells; OLGs, oligodendrocytes; P-MBP, phosphorylated myelin basic protein.