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Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 617438, 9 pages
Administration of Chinpi, a Component of the Herbal Medicine Ninjin-Youei-To, Reverses Age-Induced Demyelination
1Department of Neuroglia Cell Biology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
2Center for Kampo Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan
3Tsumura Laboratory, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan
4Biomedical Research Center, Division of Morphological Science, Saitama Medical School, 38 Morohongo, Iruma-gun, Saitama, 350-0495, Japan
5Kracie Pharmaceutical, Ltd., 1-8-63 Tenmanbashi, Kita-ku, Osaka 530-0042, Japan
6Sun R&D Institute for Natural Medicine Co. Inc., 3-12-6 Ginza, Chuo-ku, Tokyo 104-0061, Japan
7Nishiogi Animal Hospital, 4-4-5 Nishiogikita, Suginami-ku, Tokyo 167-0042, Japan
8NHK Enterprises, Inc., 4-14 Kamiyama-cho, Shibuya-ku, Tokyo 150-0047, Japan
9Kudou Chiaki Hospital, 1-23-10 Omori-kita, Ota-ku, Tokyo 143-0016, Japan
10Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kamei-cho, Fujisawa-shi, Kanagawa 252-8510, Japan
Received 9 April 2009; Accepted 29 December 2009
Copyright © 2011 Nanako Sato et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- G. M. Bray, M. Rasminsky, and A. J. Aguayo, “Interactions between axons and their sheath cells,” Annual Review of Neuroscience, vol. 4, pp. 127–162, 1981.
- I. Griffiths, M. Klugmann, T. Anderson et al., “Axonal swellings and degeneration in mice lacking the major proteolipid of myelin,” Science, vol. 280, no. 5369, pp. 1610–1613, 1998.
- C. Hildebrand, S. Remahl, H. Persson, and C. Bjartmar, “Myelinated nerve fibres in the CNS,” Progress in Neurobiology, vol. 40, no. 3, pp. 319–384, 1993.
- M. Sospedra and R. Martin, “Immunology of multiple sclerosis,” Annual Review of Immunology, vol. 23, pp. 683–747, 2005.
- S. L. Hauser and J. R. Oksenberg, “The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration,” Neuron, vol. 52, no. 1, pp. 61–76, 2006.
- J. L. McQualter and C. C. A. Bernard, “Multiple sclerosis: a battle between destruction and repair,” Journal of Neurochemistry, vol. 100, no. 2, pp. 295–306, 2007.
- G. Wolswijk, “Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells,” Journal of Neuroscience, vol. 18, no. 2, pp. 601–609, 1998.
- A. Chang, W. W. Tourtellotte, R. Rudick, and B. D. Trapp, “Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis,” The New England Journal of Medicine, vol. 346, no. 3, pp. 165–173, 2002.
- S. A. Back, T. M. F. Tuohy, H. Chen et al., “Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation,” Nature Medicine, vol. 11, no. 9, pp. 966–972, 2005.
- J. Nakahara and S. Aiso, “Fc receptor-positive cells in remyelinating multiple sclerosis lesions,” Journal of Neuropathology and Experimental Neurology, vol. 65, no. 6, pp. 582–591, 2006.
- J. Nakahara, K. Tan-Takeuchi, C. Seiwa et al., “Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation,” Developmental Cell, vol. 4, no. 6, pp. 841–852, 2003.
- C. Seiwa, M. Yamamoto, K. Tanaka et al., “Restoration of FcRγ/Fyn signaling repairs central nervous system demyelination,” Journal of Neuroscience Research, vol. 85, no. 5, pp. 954–966, 2007.
- T. Takai, M. Li, D. Sylvestre, R. Clynes, and J. V. Ravetch, “FcR γ chain deletion results in pleiotrophic effector cell defects,” Cell, vol. 76, no. 3, pp. 519–529, 1994.
- T. Yagi, S. Aizawa, T. Tokunaga, Y. Shigetani, N. Takeda, and Y. Ikawa, “A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice,” Nature, vol. 366, no. 6457, pp. 742–745, 1993.
- J. Kobayashi, C. Seiwa, T. Sakai et al., “Effect of a traditional Chinese herbal medicine, Ren-Shen-Yang-Rong-Tang (Japanese name: Ninjin-Youei-To), on oligodendrocyte precursor cells from aged-rat brain,” International Immunopharmacology, vol. 3, no. 7, pp. 1027–1039, 2003.
- C. Seiwa, J. Nakahara, T. Komiyama, Y. Katsu, T. Iguchi, and H. Asou, “Bisphenol A exerts thyroid-hormone-like effects on mouse oligodendrocyte precursor cells,” Neuroendocrinology, vol. 80, no. 1, pp. 21–30, 2004.
- N.-N. Zhou, S. Nakai, T. Kawakita et al., “Combined treatment of autoimmune MRL/MP-lpr/lpr mice with a herbal medicine, Ren-shen-yang-rong-tang (Japanese name: Ninjin-Youei-to) plus suboptimal dosage of prednisolone,” International Journal of Immunopharmacology, vol. 16, no. 10, pp. 845–854, 1994.
- F. Takano, Y. Ohta, T. Tanaka et al., “Oral administration of Ren-shen-yang-rong-tang 'Ninjin'yoeito' protects against hematotoxicity and induces immature erythroid progenitor cells in 5-fluorouracil-induced anemia,” Evidence-Based Complementary and Alternative Medicine, vol. 6, no. 2, pp. 247–256, 2009.
- R. E. Hartman, A. Shah, A. M. Fagan et al., “Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease,” Neurobiology of Disease, vol. 24, no. 3, pp. 506–515, 2006.
- O. Weinreb, S. Mandel, T. Amit, and M. B. H. Youdim, “Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases,” Journal of Nutritional Biochemistry, vol. 15, no. 9, pp. 506–516, 2004.
- D. J. Loren, N. P. Seeram, R. N. Schulman, and D. M. Holtzman, “Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury,” Pediatric Research, vol. 57, no. 6, pp. 858–864, 2005.
- A. Garg, S. Garg, L. J. D. Zaneveld, and A. K. Singla, “Chemistry and pharmacology of the citrus bioflavonoid hesperidin,” Phytotherapy Research, vol. 15, no. 8, pp. 655–669, 2001.
- O. Benavente-García and J. Castillo, “Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity,” Journal of Agricultural and Food Chemistry, vol. 56, no. 15, pp. 6185–6205, 2008.
- C. Bock, K.-H. Waldmann, and W. Ternes, “Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract,” Nutrition Research, vol. 28, no. 12, pp. 879–891, 2008.
- C. Gardana, S. Guarnieri, P. Riso, P. Simonetti, and M. Porrini, “Flavanone plasma pharmacokinetics from blood orange juice in human subjects,” British Journal of Nutrition, vol. 98, no. 1, pp. 165–172, 2007.
- C. Manach, C. Morand, A. Gil-Izquierdo, C. Bouteloup-Demange, and C. Rémésy, “Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two dose of orange juice,” European Journal of Clinical Nutrition, vol. 57, no. 2, pp. 235–242, 2003.
- D. G. Stewart and K. L. Davis, “Possible contributions of myelin and oligodendrocyte dysfunction to schizophrenia,” International Review of Neurobiology, vol. 59, pp. 381–424, 2003.