Biochanin A, a Phytoestrogenic Isoflavone with Selective Inhibition of Phosphodiesterase 4, Suppresses Ovalbumin-Induced Airway Hyperresponsiveness
Figure 4
Effects of biochanin A (10~100 μmol/kg, p.o.) on the total IgG2a (a) level in the serum, and total IgE (b, c) and OVA-specific IgE (d, e) levels in the serum (b, d), and BALF (c, e) of sensitized mice receiving aerosolized methacholine (MCh, 6.25~50 mg/mL) 2 days after primary allergen challenge. ##, and ###, compared to the nonchallenged group. *, and **, compared to the control (vehicle) group. Each value represents the mean ± SEM. The number of mice in each group was 10.
