Antioxidant and Hepatoprotective Effects of Silibinin in a Rat Model of Nonalcoholic Steatohepatitis

Table 1

Effect of silibinin on body and liver weight.

Parameters	BW (g)	WG (g)	LW (g)	LI^a (%)
Control	559 ± 18	469 ± 6	14.2 ± 0.5	2.5 ± 0.1
NASH	526 ± 15	433 ± 17	16.7 ± 0.6*	3.2 ± 0.1*
Silibinin	510 ± 12	432 ± 11	13.4 ± 0.8**	2.6 ± 0.1**
ANOVA	0.065	0.085	0.0184	0.0071

Measurements were obtained from rats on the day of sacrifice, after 12 weeks of standard diet (control) or high-fat diet alone (NASH), or supplemented with silibinin–phosphatidylcholine complex (Silibinin), at a dose of 200 mg kg⁻¹ as silibinin, during the last 5 weeks. Values are expressed as means ± SE of six rats for control and NASH groups and of eight rats for Silibinin group.
^aLI, LW/BW × 100.
* 𝑃<.05 versus control group. **𝑃<.05 versus NASH group.