Gastroprotective Properties of Karanjin from Karanja (Pongamia pinnata) Seeds; Role as Antioxidant and H+, K+-ATPase Inhibitor
Table 3
Antioxidant/antioxidant enzymes and TBARS levels in stomach homogenates of swim/ethanol stress-induced ulcer model.
Groups
GSH (nmol g−1 tissue)
TBARS (nmol mg−1 protein)
SOD (U mg−1 protein)
Catalase (μmol mg−1 protein)
Glutathione Peroxidase (nmol mg−1 protein)
Swim stress
Healthy
395.3a ± 73.9
0.16b ± 0.08
32.87a ± 3.4
15.99b ± 2.0
2.62c ± 0.2
Swim stress induced
183.9d ± 4.3
0.44a ± 0.20
15.62e ± 0.4
8.88c ± 1.5
1.30e ± 0.1
Karanjin control
315.5e ± 50.9
0.17b ± 0.20
38.16c ± 1.8
16.91b ± 2.1
2.49c ± 0.8
Karanjin 10 mg kg−1 b.w.
429.3b, c ± 50.1
0.21c ± 0.15
38.02c ± 5.3
15.40b ± 1.0
1.70a, e ± 0.7
Karanjin 20 mg kg−1 b.w.
473.8b ± 45.6
0.17b ± 0.06
44.45b ± 2.5
16.79b ± 0.9
2.38c ± 0.5
Omeprazole control
411.8a, c ± 39.6
0.16b ± 0.09
36.28a, c ± 1.7
15.20b ± 3.3
3.16b ± 1.6
Omeprazole 20 mg kg−1 b.w.
391.8a ± 44.2
0.14b ± 0.05
36.14a, c ± 3.3
15.24b ± 1.5
2.06a, c ± 0.7
Oil treated
177.8d ± 51.5
0.24a ± 0.06
15.16e ± 0.9
9.04c ± 0.9
1.40e ± 0.0
Ethanol stress
Healthy
181.5b ± 37.6
0.16b ± 0.08
Not tested
17.09a, c ± 1.5
Not tested
Ethanol stress induced
110.8e ± 40.0
0.44c ± 0.20
8.30e ± 3.3
Karanjin control
294.1b, c ± 57.1
0.17b ± 0.07
18.31b, c ± 5.0
Karanjin 10 mg kg−1 b.w.
211.5b, c ± 89.5
0.21b ± 0.05
15.36a ± 2.8
Karanjin 20 mg kg−1 b.w.
233.6a, c ± 41.3
0.17b ± 0.06
17.38b, c ± 2.3
Omeprazole control
261.5a ± 38.5
0.16b ± 0.09
19.37b ± 4.1
Omeprazole 20 mg kg−1 b.w.
210.1b ± 59.0
0.14b ± 0.05
15.82a ± 1.5
Oil treated
125.9b ± 33.8
0.44c ± 0.06
8.02e ± 1.5
Results are expressed as mean ± SD (). Range was provided by Duncan multiple-range test at . Different letters a–d in the column represent values that are significantly different when ulcer-induced group was compared with healthy control and sample-treated groups. amoderately significant; bless or not significant; cless significant and dmost significant.
