Curdione Plays an Important Role in the Inhibitory Effect of Curcuma aromatica on CYP3A4 in Caco-2 Cells
Figure 3
Inhibition of nifedipine oxidation by components from C. aromatica (MeOH extract: 0.1 mg ml−1; haxane fraction: 0.1 mg ml−1; curdione: 20 M; curcumin: 4 M). Components were applied to the apical compartment and incubated for 72 hours. After removing components, nifedipine (200 M) was added to the apical compartment and incubated for 4 hours. The amount of oxidized nifedipine in the basolateral compartment was measured. Results are means ± SD from triplicate experiments. **P < .01 versus control.
