Garlic Oil Alleviates MAPKs- and IL-6-mediated Diabetes-related Cardiac Hypertrophy in STZ-induced DM Rats

Figure 7

A schematic representation showing garlic oil ameliorates cardiac pathologic hypertrophy and subsequent cardiac dysfunction in rats with diabetes by down-regulating the activities of MAPKs (p38, JNK and ERK1/2) and IL-6/MEK5/ERK5 signaling pathways. Hyperglycemia greatly activates signaling pathways of MAPK (e.g., p38, JNK and ERK1/2) and IL-6/MEK5/ERK5, simultaneously, in the hearts of diabetic rats. These activated signaling pathways significantly induce the development of cardiac pathologic hypertrophy and the expressions of pathologic hypertrophy response genes such as ANP and BNP. In diabetic rats, treatment involving garlic oil reduces the hyperglycemia-cardiac pathologic hypertrophy and improves the heart function by efficiently de-activating MAPK (p38, JNK and ERK1/2) and IL-6/MEK5/ERK5 signaling pathways.