Involvement of Heme Oxygenase-1 Induction in the Cytoprotective and Immunomodulatory Activities of Viola patrinii in Murine Hippocampal and Microglia Cells

Figure 10

The pathway scheme of the anti-inflammatory and cytoprotective effects of NNMBS275 in BV2 microglia and HT22 cells. NNMBS275 increased cellular resistance to oxidative injury caused by glutamate-induced oxidative cytotoxicity in HT22 cells, via Nrf2-dependent HO-1 expression. In BV2 cells, NNMBS275 suppressed the LPS-induced expression of proinflammatory enzymes and inflammatory mediators through its interference of NF-κB activation and Nrf2-dependent HO-1 expression. This study indicates that NNMBS275 effectively modulates the regulation of antioxidative and anti-inflammatory action, via Nrf2 pathway dependent HO-1 expression in BV2 microglia and HT22 cells.