Understanding the Molecular Mechanism of Interventions in Treating Rheumatoid Arthritis Patients with Corresponding Traditional Chinese Medicine Patterns Based on Bioinformatics Approach
Figure 3
Molecular network based mechanism of TCM therapy in treating RA. (a) shows the pharmacological network of TCM therapy obtained with PPI analysis. Node represents protein, and edge represents interaction. Left: centrality of pharmacological network of TCM therapy. Right: 8 highly connected clusters were obtained from PPI analysis, and the correlated pathways were shown in Table 2. Greed colored nodes represent nodes affected by either Glucosidorum Tripterygll Totorum tablet or Yishen Juanbi Tablet, yellow nodes represent nodes affected by the interaction of Glucosidorum Tripterygll Totorum tablet and Yishen Juanbi Tablet. Red colored nodes represent nonaffected nodes. (b) shows the merged networks of TCM intervention pharmacological networks and RA pattern networks. Node represents protein, and edge represents interaction. Left part is for cold pattern, and right part is for hot pattern. The dots between cold and hot patterns are the intersection between the two TCM patterns. The red and green colored nodes represent the proteins which could be targeted by one of the TCM products, and the yellow nodes represent the proteins which could be targeted by both TCM products, or by the interaction between the two TCM products.
