Analgesic and Anti-Inflammatory Activities of Methanol Extract of Cissus repens in Mice

Table 1

Effect of CR_MeOH and indomethacin on MDA, NO, TNF-α, IL-1β, IL-6, and NFκB level in the edema paws.

Groups	MDA; (nmol/mg protein)	NO (μM)	TNF-α (pg/mg protein)	IL-1β (ng/mg protein)	IL-6 (ng/mg protein)	NFκB (ng/mg protein)
Carr	2.619 ± 0.163	9.956 ± 0.437	297.600 ± 15.539	929.167 ± 60.585	1483.900 ± 80.219	0.842 ± 0.088
Carr + Indomethacin	1.376 ± 0.096***	6.438 ± 0.321***	190.000 ± 11.779***	639.500 ± 14.040*	1113.500 ± 74.330*	0.527 ± 0.032**
Carr + CRMeOH (20 mg/kg)	2.328 ± 0.149	7.699 ± 0.398*	250.000 ± 16.441	922.000 ± 76.033	1239.000 ± 70.825	0.538 ± 0.039**
Carr + CRMeOH (100 mg/kg)	2.001 ± 0.187*	6.918 ± 0.318***	212.000 ± 8.569**	740.000 ± 35.407	1022.400 ± 89.513**	0.516 ± 0.042***
Carr + CRMeOH (500 mg/kg)	1.274 ± 0.065***	6.222 ± 0.501***	191.917 ± 9.339***	606.000 ± 50.212**	978.444 ± 44.539***	0.493 ± 0.014***

Each value represents the mean ± S.E.M. (n = 8). *P < 0.05, **P < 0.01, and ***P < 0.001 as compared with the λ-carrageenan (Carr) group (one-way ANOVA followed by Scheffe’s multiple range test).