Evidence for Inhibitory Effects of Flupirtine, a Centrally Acting Analgesic, on Delayed Rectifier K+ Currents in Motor Neuron-Like Cells
Figure 1
Effects of Flu on in NSC-34 neuronal cells. Cells were bathed in Ca2+-free Tyrode’s solution containing tetrodotoxin (1 M) and CdCl2 (0.5 mM). (a) Superimposed current traces in the absence (upper) and presence (lower) of 3 M Flu. The cell examined was held at −50 mV and various potentials ranging from −100 to +40 mV in 10-mV increments, as shown in the uppermost part of (a), were applied. (b) Averaged relations for K+ currents measured at the end of each voltage pulse in the absence (■) and presence (□) of 3 M Flu (mean ± SEM; –13 for each point). (c) The relationship of Flu-sensitive current (i.e., the difference of averaged K+ currents between the absence and presence of 3 M Flu).
