Table 1: Target proteins of Fu Zi, Xi Xin, and Gui Zhi searched in PubChem.

Active compoundsHomosapiens proteins nameGI number

Higenamine D(2) dopamine receptor118206

Fuziline Orexin receptor type 1 222080095

Caspase 82493531
Vitamin D3 receptor isoform VDRA 63054845
Microtubule-associated protein tau 92096784
Safrole Corticotropin-releasing hormone receptor 2 38349113
Aldehyde dehydrogenase 1 family, member A1 30582681
Euchromatic histone-lysine N-methyltransferase 2168985070
Corticotropin releasing factor-binding protein 30219

Farnesoid X nuclear receptor325495553
Methyleugenol Sentrin-specific protease 8 262118306
AR protein 124375976

Asaricin Cytochrome P450 3A4 isoform 113435386

Sentrin-specific protease 8 262118306
Cytochrome P450 1A2 73915100
Asarinin Cytochrome P450 2D6 isoform 140805836
Cytochrome P450 2C9 precursor13699818
Cytochrome P450 2C19 precursor4503219

Transient receptor potential cation channel subfamily A member 1313104269
cGMP-specific 3′,5′-cyclic phosphodiesterase317373261
Lamin isoform A delta 10 27436948
Cinnamaldehyde Prothrombin 339641
Glucocorticoid receptor311348376
Aldehyde dehydrogenase 1 family, member A1 30582681
Chain A, crystal structure of the human 2-oxoglutarate oxygenase Loc390245221046486
Glucocerebrosidase496369

Thromboxane-A synthase254763392
Heat shock protein HSP 90-alpha isoform 2 154146191
Melanocortin receptor 4 119508433
Lysosomal alpha-glucosidase preproprotein 119393891
Alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor 116734717
Tyrosine-protein kinase ABL1 isoform a62362414
Nuclear receptor coactivator 3 isoform a32307126
Nuclear receptor coactivator 1 isoform 1 22538455
MPI protein 16878311
Glyceraldehyde-3-phosphate dehydrogenase isoform 1 7669492
Glutathione S-transferase omega-1 isoform 1 4758484
Tyrosinase401235
Arachidonate 5-lipoxygenase126407
Carbonic anhydrase 2115456
Cytochrome P450 2A6308153612
Carbonic anhydrase 3134047703
Carbonic anhydrase 6116241278
Carbonic anhydrase 983300925
Hydroxycarboxylic acid receptor 274762622
Carbonic anhydrase 5B, mitochondrial8928041
Carbonic anhydrase 148928036
5-hydroxytryptamine receptor 78488960
Epidermal growth factor receptor2811086
Carbonic anhydrase 71168744
Cinnamic acidCarbonic anhydrase 5A, mitochondrial461680
Tyrosine-protein phosphatase non-receptor type 1131467
Carbonic anhydrase 4115465
Carbonic anhydrase 1115449
Adenosine receptor A2b112938
Lethal(3)malignant brain tumor-like protein 1 isoform I 117938328
5-hydroxytryptamine receptor 5A13236497
potassium voltage-gated channel subfamily H member 2 isoform d325651834
DNA polymerase iota 154350220
DNA polymerase kappa 7705344
DNA polymerase eta 5729982
DNA polymerase beta4505931
Estrogen receptor beta isoform 110835013
Nuclear receptor subfamily 0 group B member 15016090
Thyroid hormone receptor beta189491771
15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 31542939
FAD-linked sulfhydryl oxidase ALR54112432
Ras and Rab interactor 1 68989256
Integrin alpha-4 precursor 67191027
Chain A, human Ape1 endonuclease with bound abasic DNA And Mn2+ Ion6980812
Mcl-1 7582271
Chain A, structure of human Recq-like helicase in complex with a DNA Substrate282403581
Chain A, Jmjd2a tandem tTudor domains in complex with a trimethylated histone H4-K20 peptide162330054
Euchromatic histone-lysine N-methyltransferase 2168985070
Chain B, the structure of wild-type human Hadh2 bound to Nad+ At 1.2 A122921311
Chain A, the structure of wild-type human Hadh2 bound to Nad+ At 1.2 A122921310
Bromodomain adjacent to zinc finger domain 2B6683500
Carbonic anhydrase 125915866