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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 153568, 7 pages
http://dx.doi.org/10.1155/2012/153568
Research Article

Inhibitory Effect of Nelumbo nucifera (Gaertn.) on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

1Department of Oriental Medicine Resources, College of Natural Science, Mokpo National University, 61 Muan-gun, Jeollanam-do 534-729, Republic of Korea
2Jeollanamdo Institute of Natural Resources Research, Jangheung-gun, Jeollanam-do 529-851, Republic of Korea
3Department of Clinical Pathology, Taekyeung College, Gyeungsan, Gyeongsangbuk-do 712-719, Republic of Korea

Received 5 October 2011; Revised 8 November 2011; Accepted 15 November 2011

Academic Editor: Shrikant Anant

Copyright © 2012 Rajendra Karki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease which has a complex etiology that encompasses immunologic responses. The study was carried out to examine the effect of Nelumbo nucifera (Gaertn.) leaf (NL) on the AD-like skin lesion induced by repeated epicutaneous application of 2,4-dinitrochlorobenzene (DNCB) on the dorsal skin of NC/Nga mice. Three different doses of NL (5, 25, and 50 mg/mice/day) were administered orally from the day of sensitization with DNCB for 4 weeks. The efficacy of NL was judged by histopathological examination, blood IgE level, measurement of transepidermal water loss (TEWL), scratching behavior, and skin severity score. NL resulted in the suppression of clinical severity score, TEWL, scratching behavior, and blood IgE level. Histopathologic analyses revealed that thickening of the epidermis and mast cell degranulation was significantly reduced in NL group. These results suggest that NL may be a useful natural resource for the management of AD.