About this Journal Submit a Manuscript Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 153568, 7 pages
http://dx.doi.org/10.1155/2012/153568
Research Article

Inhibitory Effect of Nelumbo nucifera (Gaertn.) on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

1Department of Oriental Medicine Resources, College of Natural Science, Mokpo National University, 61 Muan-gun, Jeollanam-do 534-729, Republic of Korea
2Jeollanamdo Institute of Natural Resources Research, Jangheung-gun, Jeollanam-do 529-851, Republic of Korea
3Department of Clinical Pathology, Taekyeung College, Gyeungsan, Gyeongsangbuk-do 712-719, Republic of Korea

Received 5 October 2011; Revised 8 November 2011; Accepted 15 November 2011

Academic Editor: Shrikant Anant

Copyright © 2012 Rajendra Karki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Y. M. Leung and N. A. Soter, “Cellular and immunologic mechanisms in atopic dermatitis,” Journal of the American Academy of Dermatology, vol. 44, no. 1, supplement 1, pp. S1–S12, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. H. C. Williams, “Is the prevalence of atopic dermatitis increasing?” Clinical and Experimental Dermatology, vol. 17, no. 6, pp. 385–391, 1992. View at Publisher · View at Google Scholar · View at Scopus
  3. C. F. Wahlgren, “Pathophysiology of itching in urticaria and atopic dermatitis,” Allergy, vol. 47, no. 2 I, pp. 65–75, 1992. View at Scopus
  4. C. Vestergaard, H. Yoneyama, M. Murai et al., “Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions,” The Journal of Clinical Investigation, vol. 104, no. 8, pp. 1097–1105, 1999. View at Scopus
  5. H. Jin, R. He, M. Oyoshi, and R. S. Geha, “Animal models of atopic dermatitis,” The Journal of Investigative Dermatology, vol. 129, no. 1, pp. 31–40, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. P. O. Fiset, D. Y. M. Leung, and Q. Hamid, “Immunopathology of atopic dermatitis,” The Journal of Allergy and Clinical Immunology, vol. 118, no. 1, pp. 287–290, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. H. P. Van Bever, “Recent advances in the pathogenesis of atopic dermatitis,” European Journal of Pediatrics, vol. 151, no. 12, pp. 870–873, 1992. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Watanabe, Y. Tomimori, K. Saito et al., “Chymase inhibitor improves dermatitis in NC/Nga mice,” International Archives of Allergy and Immunology, vol. 128, no. 3, pp. 229–234, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Matsuda, N. Watanabe, G. P. Geba et al., “Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice,” International Immunology, vol. 9, no. 3, pp. 461–466, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Nagai, A. Matsuo, H. Hiyama, N. Inagaki, and K. Kawada, “Immunoglobulin E production in mice by means of contact sensitization with a simple chemical, hapten,” The Journal of Allergy and Clinical Immunology, vol. 100, no. 6, pp. S39–S44, 1997. View at Scopus
  11. H. Kitagaki, N. Ono, K. Hayakawa, T. Kitazawa, K. Watanabe, and T. Shiohara, “Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile,” The Journal of Immunology, vol. 159, no. 5, pp. 2484–2491, 1997. View at Scopus
  12. Y. Ono, E. Hattori, Y. Fukaya, S. Imai, and Y. Ohizumi, “Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats,” Journal of Ethnopharmacology, vol. 106, no. 2, pp. 238–244, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. E. Ohkoshi, H. Miyazaki, K. Shindo, H. Watanabe, A. Yoshida, and H. Yajima, “Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice,” Planta Medica, vol. 73, no. 12, pp. 1255–1259, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. J. H. Oh, B. J. Choi, M. S. Chang, and S. K. Park, “Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression,” Neuroscience Letters, vol. 461, no. 1, pp. 41–44, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. J. Wang, X. Hu, W. Yin, and H. Cai, “Alkaloids of plumula Nelumbinis,” Zhongguo zhong yao za zhi, vol. 16, no. 11, pp. 673–703, 1991.
  16. H. C. William, “Atopic dermatitis,” The New England Journal of Medicine, vol. 352, no. 22, pp. 2314–2366, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. T. Sasakawa, Y. Higashi, S. Sakuma et al., “Atopic dermatitis-like skin lesions induced by topical application of mite antigens in NC/Nga mice,” International Archives of Allergy and Immunology, vol. 126, no. 3, pp. 239–247, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Q. Man, Y. Hatano, S. H. Lee et al., “Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges,” The Journal of Investigative Dermatology, vol. 128, no. 1, pp. 79–86, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. S. Romagnani, “Immunologic influences on allergy and the TH1/TH2 balance,” The Journal of Allergy and Clinical Immunology, vol. 113, no. 3, pp. 395–400, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. D. D. Metcalfe, D. Baram, and Y. A. Mekori, “Mast cells,” Physiological Reviews, vol. 77, no. 4, pp. 1033–1079, 1997. View at Scopus
  21. J. R. Gordon, P. R. Burd, and S. J. Galli, “Mast cells as a source of multifunctional cytokines,” Immunology Today, vol. 11, no. 12, pp. 458–464, 1990. View at Scopus
  22. S. Ständer and M. Steinhoff, “Pathophysiology of pruritus in atopic dermatitis: an overview,” Experimental Dermatology, vol. 11, no. 1, pp. 12–24, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. C. W. Blichmann and J. Serup, “Assessment of skin moisture. Measurement of electrical conductance, capacitance and transepidermal water loss,” Acta Dermato-Venereologica, vol. 68, no. 4, pp. 284–290, 1988. View at Scopus
  24. K. Morikawa, M. Nonaka, M. Narahara et al., “Inhibitory effect of quercetin on carrageenan-induced inflammation in rats,” Life Sciences, vol. 74, no. 6, pp. 709–721, 2003. View at Publisher · View at Google Scholar · View at Scopus