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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 164152, 11 pages
http://dx.doi.org/10.1155/2012/164152
Review Article

Earthworms Dilong: Ancient, Inexpensive, Noncontroversial Models May Help Clarify Approaches to Integrated Medicine Emphasizing Neuroimmune Systems

1Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan
2Laboratory of Comparative Neuroimmunology, Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095-1763, USA
3Division of Vermibiotechnology, Department of Zoology, Annamalai University, Annamalai Nagar-608002, India
4Graduate Institute of Basic Medical Science and Graduate Institute of Chinese Medical Science, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
5Department of Biology and Department of Sociology, University of California, Los Angeles, Los Angeles, CA 90024, USA
6Department of Linguistics, University of California, Los Angeles, Los Angeles, CA 90024, USA
7Department of Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
8Department of Biology, University of Padua, Via U. Bassi, 58/b, 35121-Padua, Italy

Received 9 December 2011; Revised 20 March 2012; Accepted 1 April 2012

Academic Editor: Bashar Saad

Copyright © 2012 Edwin L. Cooper et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Z. Herbert, E. Pollák, A. Zougman, A. Boros, N. Kapan, and L. Molnár, “Identification of novel neuropeptides in the ventral nerve cord ganglia and their targets in an annelid worm, Eisenia fetida,” Journal of Comparative Neurology, vol. 514, no. 5, pp. 415–432, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Engelmann, E. L. Cooper, B. Opper, et al., “Earthworm innate immune system in biology of earthworms,” Soil Biology, vol. 24, pp. 229–245, 2011.
  3. M. Bilej, P. Procházková, M. Šilerová, and R. Josková, “Earthworm immunity,” Advances in Experimental Medicine and Biology, vol. 708, pp. 66–79, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Boros, I. Somogyi, P. Engelmann et al., “Pituitary adenylate cyclase-activating polypeptide type 1 (PAC1) receptor is expressed during embryonic development of the earthworm,” Cell and Tissue Research, vol. 339, no. 3, pp. 649–653, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Wilhelm, A. Koza, P. Engelmann, P. Németh, and M. Csoknya, “Evidence for the presence of thyroid-stimulating hormone, thyroglobulin and their receptors in Eisenia fetida: a multilevel hormonal interface between the nervous system and the peripheral tissues,” Cell and Tissue Research, vol. 324, no. 3, pp. 535–546, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Darwin, The Formation of Vegetable Mold Through the Action of Worms, Willam Clowes and Sons, London, UK, 1881.
  7. M. G. Paoletti, “The role of earthworms for assessment of sustainability and as bioindicators,” Agriculture, Ecosystems and Environment, vol. 74, no. 1–3, pp. 137–155, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. V. Tanara, L’economia del cittadino in villa, Venezia, Italy, 1644.
  9. R. Fan, “The new medicine "lumbrokinase capsules" for treatment and prevention of thrombus and embolic diseases,” Institute of Biophysics, Academia Sinica, pp. 1–7.
  10. E. L. Cooper, “Complementary and Alternative Medicine, When Rigorous, can be Science,” Evidence-Based Complementary and Alternative Medicine, vol. 1, no. 1, pp. 1–4, 2004.
  11. E. L. Cooper, B. Ru, N. Weng, et al., “Earthworms: sources of antimicrobial and anticancer molecules,” in Complementary and Alternative Approaches to Biomedicine, pp. 359–390, Kluwer Academic/Plenum, New York, NY, USA, 2004.
  12. E. L. Cooper, “CAM, eCAM, bioprospecting: the 21st century pyramid,” Evidence-based Complementary and Alternative Medicine, vol. 2, no. 2, pp. 125–127, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. J. W. Reynolds and W. M. Reynolds, “Earthworms in medicine,” American Journal of Nursing, vol. 72, no. 7, p. 1273, 1972. View at Scopus
  14. J. Stevenson, Oligochaeta, Claredon Press, Oxford, UK, 1930.
  15. G. E. Gates, “The Earthworms of Rangoon,” Journal of the Burma Research Society, vol. 25, pp. 196–221, 1926.
  16. H. Azaizeh, B. Saad, E. Cooper, and O. Said, “Traditional Arabic and Islamic medicine, a re-emerging health aid,” Evidence-based Complementary and Alternative Medicine, vol. 7, no. 4, pp. 419–424, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Rozin, A. Fallon, and R. Mandell, “Family resemblance in attitudes to foods,” Developmental Psychology, vol. 20, no. 2, pp. 309–314, 1984. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Darwin, The Expression of Emotions in Man and Animals, University of Chicago Press, Chicago, Ill, USA, 1965.
  19. A. Angyal, “Disgust and related aversions,” Journal of Abnormal and Social Psychology, vol. 36, no. 3, pp. 393–412, 1941. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Prokop and J. Fančovičová, “The association between disgust, danger and fear of macroparasites and human behaviour,” Acta Ethologica, vol. 13, no. 1, pp. 57–62, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. H. S. Bristowe, “Insects and other invertebrates for human consumption in Siam,” Transitional Entological Sociology, vol. 80, pp. 387–404, 1932.
  22. M. G. Paoletti and D. L. Dufour, Minilivestock. Encyclopedia of Pest Management, M. Dekker, New York, NY, USA, 2002.
  23. M. G. Paoletti and D. L. Dufour, “Edible invertebrates among Amazonian Indians: a critical review of Disappearing Knowledge,” in Ecological Implications of Minelivestock, pp. 293–342, Science Publishers, Enfield, NH, USA, 2005.
  24. S. Zhenjun, Nutritive value of Earthworms”. Ecological implications of Minilivestock, Science Publishers, Inc., Enfield, NH, USA, 2005.
  25. J. Gernet, La vie quotidienne en Chine à la vieille de l’invasion mongole: 1250–1276, Hachette, Paris, France, 1959.
  26. Z. Zeng, G. Zhang, and Q. Xu, Earthworm Cultures, Hubei People’s Publ. House, Wuhan, China, 1982.
  27. D. Zimian, Z. Yonghua, and G. Xivu, “Medicinal Terrestrial Arthropods in China,” in Ecological Implications of Minilivestock, pp. 482–484, Science Publishers, 2005.
  28. W. Bristowe, “Insects and other invertebrates for Human consumption in Siam,” Transactions of the Entomological Society, vol. 80, no. 2, pp. 387–404, 1932.
  29. P. Ljungström and A. Reinecke, “Ecology and Natural History of the microchaetid earthworms of South Africa,” Pedobiologia, vol. 9, pp. 152–157, 1969.
  30. L. G. K Carr, “Interesting animal foods, medicines and omens of the eastern Indians, with comparisons to ancient European practices,” Journal of the Washington Academy of Sciences, vol. 41, pp. 229–235, 1951.
  31. S. F. Price, “Kentucky Folklore,” Journal of American Folklore, vol. 14, pp. 30–38, 1901.
  32. E. L. Cooper and N. Yamaguchi, Complementary and alternative approaches to biomedicine; Advances in Experimental Medicine and Biology, Springer, New York, NY, USA, 2004.
  33. W. Benham, “On some Edible and other New Species of Earthworms from the North Island of New Zealand,” Proceedings of the Zoological Society of London, vol. 74, no. 4, pp. 220–263, 1904.
  34. E. Best, “The food products of the Tuhoe-Land,” Transactions of the New Zealand Institute, vol. 25, pp. 41–111, 1902.
  35. B. Spencer and F. Gillen, The Northern Tribes of Central Australia, MacMillan and Co. Ltd., London, UK, 1904.
  36. V. Grottanelli, Ethnologica. L’Uomo e la Civiltà, vol. 3, Labor, Milano, Italy, 1965.
  37. M. Tommaseo-Ponzetta, “Personal Communication”.
  38. V. B. Meyer-Rochow, “Food taboos: their origins and purposes,” Journal of Ethnobiology and Ethnomedicine, vol. 5, article no. 18, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. M. G. Paoletti, E. Buscardo, D. J. VanderJagt et al., “Nutrient content of earthworms consumed by Ye'Kuana Amerindians of the Alto Orinoco of Venezuela,” Proceedings of the Royal Society B: Biological Sciences, vol. 270, no. 1512, pp. 249–257, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. Y.-M. Chang, W.-H. Kuo, T.-Y. Lai et al., “RSC96 Schwann cell proliferation and survival induced by dilong through PI3K/Akt signaling mediated by IGF-I,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 216148, 9 pages, 2011. View at Publisher · View at Google Scholar
  41. Z. Sun, X. Liu, L. Sun, and C. Song, “Earthworm as a potential protein resource,” Ecology of Food Nutrition, vol. 36, no. 2–4, pp. 221–236, 1997. View at Scopus
  42. K. Patwardhan, S. Gehlot, G. Singh, and H. C. S. Rathore, “The Ayurveda education in India: how well are the graduates exposed to basic clinical skills?” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 197391, 6 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. K. Joshi, Y. Ghodke, and B. Patwardhan, “Traditional medicine to modern pharmacogenomics: Ayurveda Prakriti type and CYP2C19 gene polymorphism associated with the metabolic variability,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 249528, 5 pages, 2011. View at Publisher · View at Google Scholar
  44. B. H. Koh, J. Y. Kim, and D. D. Pham, “Comparison of sasang constitutional medicine, traditional chinese medicine and ayurveda,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 239659, 6 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. Y.-M. Chang, W.-Y. Chi, T.-Y. Lai et al., “Dilong: role in peripheral nerve regeneration,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 380809, 9 pages, 2011. View at Publisher · View at Google Scholar
  46. E. L. Cooper, M. Balamurugan, K. Parthasarathi, and L. S. Ranganathan, “Earthworm paste (Lampito mauritii, Kinberg) alters inflammatory, oxidative, haematological and serum biochemical indices of inflamed rat,” European Review for Medical and Pharmacological Sciences, vol. 11, no. 2, pp. 77–90, 2007. View at Scopus
  47. E. L. Cooper, “New enzyme complex isolated from earthworms is potent fibrinolytic,” Focus (Allergy Research Group), pp. 1–5, 2009.
  48. M. Prakash, M. Balamurugan, K. Parthasarathi, G. Gunasekaran, E. L. Cooper, and L. S. Ranganathan, “Anti-ulceral and anti-oxidative properties of “earthworm paste” of Lampito mauritii (Kinberg) on Rattus Norvegicus,” European Review for Medical and Pharmacological Sciences, vol. 11, no. 1, pp. 9–15, 2007. View at Scopus
  49. M. Balamurugan, K. Parthasarathi, L. S. Ranganathan, and E. L. Cooper, “Hypothetical mode of action of earthworm extract with hepatoprotective and antioxidant properties,” Journal of Zhejiang University: Science B, vol. 9, no. 2, pp. 141–147, 2008. View at Publisher · View at Google Scholar · View at Scopus
  50. M. Balamurugan, K. Parthasarathi, E. L. Cooper, and L. S. Ranganathan, “Anti-inflammatory and anti-pyretic activities of earthworm extract-Lampito mauritii (Kinberg),” Journal of Ethnopharmacology, vol. 121, no. 2, pp. 330–332, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. E. L. Cooper, T. M. Hrzenjak, and M. Grdiša, “Alternative sources of fibrinolytic, anticoagulative, antimicrobial and anticancer molecules,” International Journal of Immunopathology and Pharmacology, vol. 17, no. 3, pp. 237–244, 2004. View at Scopus
  52. S. Wei, X. Yin, Y. Kou, and B. Jiang, “Lumbricus extract promotes the regeneration of injured peripheral nerve in rats,” Journal of Ethnopharmacology, vol. 123, no. 1, pp. 51–54, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. C. Y. Huang, Y. M. Chang, Y. T. Shih et al., “Schwann cell migration induced by earthworm extract via activation of PAs and MMP2/9 mediated through ERK1/2 and p38,” Evidence-based Complementary and Alternative Medicine, vol. 2011, Article ID 395458, 12 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  54. C. T. Chen, J. G. Lin, T. W. Lu et al., “Earthworm extracts facilitate pc12 cell differentiation and promote axonal sprouting in peripheral nerve injury,” American Journal of Chinese Medicine, vol. 38, no. 3, pp. 547–560, 2010. View at Publisher · View at Google Scholar · View at Scopus
  55. E. L. Cooper, “Evolution of immune systems from self/not self to danger to artificial immune systems (AIS),” Physics of Life Reviews, vol. 7, no. 1, pp. 55–78, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. E. L. Cooper and M. Balamurugan, “Unearthing a source of medicinal molecules,” Drug Discovery Today, vol. 15, no. 21-22, pp. 966–972, 2010. View at Publisher · View at Google Scholar · View at Scopus
  57. E. L. Cooper, “Earthworms: harnessing one of nature's cancer killers,” Oncology Journal, vol. 19, no. 7, p. 21, 2010.
  58. S. Y. Pan, S. B. Chen, H. G. Dong et al., “New perspectives on Chinese herbal medicine (Zhong-Yao) research and development,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 403709, 11 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  59. T. Eu and Y. Sang, Heritage an Anthology of Chinese Herbs and Medicines, Eu Yan Sang International Holdings. Pte Ltd, Singapore, 1995.
  60. A. Manca, S. Capsoni, A. Di Luzio et al., “Nerve growth factor regulates axial rotation during early stages of chick embryo development,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 6, pp. 2009–2014, 2012. View at Publisher · View at Google Scholar
  61. J. D. Lee, H. J. Park, Y. Chae, and S. Lim, “An overview of bee venom acupuncture in the treatment of arthritis,” Evidence-Based Complementary and Alternative Medicine, vol. 2, no. 1, pp. 79–84, 2005. View at Publisher · View at Google Scholar · View at Scopus
  62. G. C. Franchi Jr., C. S. Moraes, V. C. Toreti, A. Daugsch, A. E. Nowill, and Y. K. Park, “Comparison of effects of the ethanolic extracts of brazilian propolis on human leukemic cells as assessed with the MTT assay,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 918956, 6 pages, 2012. View at Publisher · View at Google Scholar
  63. Y. Nigam, A. Bexfield, S. Thomas, and N. A. Ratcliffe, “Maggot therapy: the science and implication for CAM part II—maggots combat infection,” Evidence-Based Complementary and Alternative Medicine, vol. 3, no. 3, pp. 303–308, 2006. View at Publisher · View at Google Scholar · View at Scopus
  64. I. S. Whitaker, O. Oboumarzouk, W. M. Rozen et al., “The efficacy of medicinal leeches in plastic and reconstructive surgery: a systematic review of 277 reported clinical cases,” Microsurgery, vol. 32, no. 3, pp. 240–250, 2012. View at Publisher · View at Google Scholar