Table 1: Effects of trigonelline on serum lipid parameters and body weight gain in diabetic rats.

GroupHbA1c (%)Serum insulin (mU/L)Insulin sensitivity indexTriglyceride (mmol/L)Total cholesterol (mmol/L)Weight gain (g)

Control37.41 ± 8.5333.24 ± 7.59−2.31 ± 0.111.76 ± 0.240.76 ± 0.13253.7 ± 18.0
Diabetes59.44 ± 10.12*47.16 ± 7.60*−3.09 ± 0.06*2.42 ± 0.46*2.14 ± 0.18*137.3 ± 7.6*
Diabetes + trigonelline39.50 ± 10.75##36.80 ± 8.13##−2.38 ± 0.12##1.85 ± 0.21##0.79 ± 0.13##103.0 ± 4.3##
Diabetes + sitagliptin37.69 ± 7.81##45.79 ± 8.01−2.46 ± 0.112.56 ± 0.512.18 ± 0.24139.2 ± 12.3#

Data are given as mean ± SD, . *P < 0.01, compared with control rats; #P < 0.05, ##P < 0.01, compared with diabetes rats.