Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy

Table 2

Effects of trigonelline on motor and sensory nerve conduction velocity and tail flick latency in diabetic rats.

Group	Motor nerve conduction velocity (m/s)	Sensory nerve conduction velocity (m/s)	Tail flick latency in cold immersion (s)	Tail flick latency in hot immersion (s)
Control	55.34 ± 5.92	57.61 ± 6.85	14.5 ± 1.0	14.2 ± 0.9
Diabetes	35.04 ± 4.36*	40.17 ± 4.03*	5.2 ± 1.0*	6.3 ± 0.7*
Diabetes + trigonelline	49.74 ± 5.05^##	51.76 ± 4.82^##	12.4 ± 1.1^##	12.0 ± 1.3^##
Diabetes + sitagliptin	41.05 ± 5.27^#	47.68 ± 3.38^##	10.8 ± 0.8^##	10.7 ± 1.0^##

Data are given as mean ± SD, n = 10. *P < 0.01, compared with control rats; ^#P < 0.05, ^##P < 0.01, compared with diabetes rats.