Table 3: Effects of trigonelline on GLP-1 level in serum and GLP-1R mRNA expression in sciatic nerve.

GroupGLP-1 level in serum (pmol/L)Sciatic nerve GLP-1R mRNA

Control19.06 ± 2.651.00 ± 0.00
Diabetes12.42 ± 1.11*0.49 ± 0.08*
Diabetes + trigonelline18.90 ± 1.25#1.03 ± 0.12#
Diabetes + sitagliptin18.27 ± 1.22#1.08 ± 0.12#

CT (threshold cycle) = CT (target gene) − CT (β-actin), CT = CT (other rats) −   CT (control rats), relative fold = , and control rat is 1. Data are given as mean ± SD, n = 10. *P < 0.01, compared with control rats; #P < 0.01, compared with diabetes rats.