Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats

Figure 4

The gross liver morphology (A1–F1) and photomicrography of liver sections (A2-F2) of rats treated with TAA and administered with P. giganteus at doses of 0.5 g/kg, 1 g/kg, and distilled water. The rats in TAA, silymarin, and P. giganteus treatment groups were injected with TAA via the intraperitoneal-route thrice a week. (A1 and A2) control rat (distilled water); (B1 and B2) control rat (P. giganteus); (C1 and C2) TAA control rat: gross image shows many micro- and macronodules in the liver (arrow), while light micrograph shows thick fibrotic septae with proliferation of bile duct (arrow); (D1 and D2) Rat administered with silymarin. (E1 and E2) rat administered with low dose of P. giganteus (0.5 g/kg): micronodules were noted in the gross image (arrow), light micrograph shows narrow fibrotic septae (arrow); (F1 and F2) rat administered with high dose of P. giganteus (1 g/kg): very minor fibrotic septae was observed in the light micrograph (arrow). (Figure A2–F2: H&E stain, original magnification: 20x).