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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 185167, 13 pages
The Inhibition of Spinal Astrocytic JAK2-STAT3 Pathway Activation Correlates with the Analgesic Effects of Triptolide in the Rat Neuropathic Pain Model
1Department of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an 710032, China
2Department of Anesthesiology, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China
3Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China
Received 19 August 2012; Accepted 16 November 2012
Academic Editor: Mei Tian
Copyright © 2012 Jun Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [6 citations]
The following is the list of published articles that have cited the current article.
- Yong-Liang Jiang, Xiao-Hu Yin, Ya-Fang Shen, Xiao-Fen He, and Jian-Qiao Fang, “Low Frequency Electroacupuncture Alleviated Spinal Nerve Ligation Induced Mechanical Allodynia by Inhibiting TRPV1 Upregulation in Ipsilateral Undamaged Dorsal Root Ganglia in Rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–9, 2013.
- Xiao-Jiaoyang Li, Zhen-Zhou Jiang, and Lu-yong Zhang, “Triptolide: Progress on research in pharmacodynamics and toxicology,” Journal of Ethnopharmacology, vol. 155, no. 1, pp. 67–79, 2014.
- Zhao-jing xue, Le Shen, Zhi-yao Wang, Shang-yi Hui, Yu-guang Huang, and Chao Ma, “STAT3 inhibitor WP1066 as a novel therapeutic agent for bCCI neuropathic pain rats,” Brain Research, 2014.
- Li-Hua Hang, Shu-Na Li, Dong-Hua Shao, Zheng Chen, Yuan-Feng Chen, and Wei-Wei Shu, “Evidence for Involvement of Spinal RANTES in the Antinociceptive Effects of Triptolide, a Diterpene Triepoxide, in a Rat Model of Bone Cancer Pain,” Basic & Clinical Pharmacology & Toxicology, 2014.
- Jun Tang, Chao Zhu, Zhi-hong Li, Xiao-yu Liu, Shu-kai Sun, Ting Zhang, Zhuo-jing Luo, Hui Zhang, and Wei-yan Li, “Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain,” Journal of Neuroinflammation, vol. 12, 2015.
- Shenbin Liu, Wen-Li Mi, Qian Li, Meng-Ting Zhang, Ping Han, Shan Hu, Qi-Liang Mao-Ying, and Yan-Qing Wang, “Spinal IL-33/ ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII- CREB and Astroglial JAK2-STAT3 Cascades in Mice,” Anesthesiology, vol. 123, no. 5, pp. 1154–1169, 2015.