Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo

Table 4

Visual scoring results. Test emulsion contained with 0.1% ASE with ROL 2500 IU; control: control emulsion with ROL 2500 IU.

Subject	0.1% ASE + ROL 2500 IU	Control (ROL 2500 IU)
#1	3	3
#2	4	4
#3	4	5
#4	1	2
#5	0	2
#6	0	0
#7	1	2
#8	0	4
#9	4	12
#10	0	7
#11	1	3
#12	2	3
#13	0	1
#14	6	6
#15	0	17
#16	5	12
#17	5	8
#18	0	10
#19	4	10
#20	1	0
#21	0	1
Sum^†	41	112
Mean^‡	1.95 *	5.33

^†means as sum value of the daily irritation scores of all subjects for a test compound. A maximum score was 1260 (21 persons × 15 days × 4).
^‡calculated as follows: mean = sum/n (the number of subjects; 𝑛=21).
* P < 0.01 was calculated versus control (retinol treated).